Cotton Blend Pajamas

Cotton blend pajamas offer the perfect combination of comfort and durability for a restful night's sleep. Crafted to provide lasting value, these pajamas are designed with your relaxation in mind, making them an essential addition to your nightly routine. The soft, breathable fabric ensures you stay cozy throughout the night while maintaining a timeless style that suits everyone. Whether you're lounging at home or settling in for a good night's rest, our versatile cotton blend pajamas are sure to become your go-to choice for ultimate comfort and ease.

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298 Items

Women's L.L.Bean Camp PJ Set
Price was from: $79 now: $64.99

A super comfortable deep marine blue PJ set with a flannel pant and jersey-knit cotton top.

Pros: High quality Perfect fit Warmth Softness Comfortable
Women's Super-Soft Shrink-Free Pajama Set, Button-Front

A bright navy, shrink-free pajama set in a supersoft cotton blend with adjustable drawstring pants.

Pros: No shrinkage True to size Comfortable Super soft Adjustable drawstring waist
Women's Super-Soft Shrink-Free Button Front Pajama Set, Stripe

A blue striped pajama set in a supersoft cotton blend with a button-front top and adjustable drawstring pants.
Women's Restorative Sleepwear Sleep Pants, Print
Price was from: $69.95 now: $59.99

A soft, lightweight green cotton-blend sleep pant with a butterfly hem and comfortable elastic waistband.

Pros: Versatile design Durable material Good value Soft fabric Comfortable fit
Women's Super-Soft Shrink-Free Pajamas, Short Set

A blue cotton-blend pajama short set featuring a button-front top and adjustable drawstring shorts.

Pros: Super-soft fabric High quality Exceptional comfort
Women's Soft Waffle Sleep Set
Price was from: $89 now: $74.99

A cozy green waffle sleep set in a cotton blend, perfect for lounging or casual outings.
Daybreak Pajama Set
Price was from: $74 now: $49.99

A cozy cotton-blend pajama set in rose shadow with a knit top and drawstring pants.
Women's Super-Soft Shrink-Free Pajamas, Short Set Stripe
Price was from: $79 now: $64.99

A pink striped pajama short set in a supersoft, shrink-free cotton blend with contrast piping details.
Men's Bean's Cotton Knit Pajamas, Button-Front PJ Set

A classic black pajama set crafted from soft 80% cotton and 20% recycled cotton interlock knit.
Women's Bean's Seacoast Seersucker Pajama Pant Set

A comfy sleep set with a soft-knit scoopneck top and airy seersucker pants with pockets.
Women's Restorative Sleepwear, Long-Sleeve Henley
Price was from: $59.95 now: $49.99

A lightweight, lavender ice long-sleeve Henley sleep top made from a soft 50% pima cotton, 50% modal blend.
Women's Restorative Sleepwear, Long-Sleeve Henley Print
Price was from: $69.95 now: $54.99

A lightweight, chalk blue geo sleep top made from a soft 50% pima cotton and 50% modal blend.
Men's Wicked Cozy Flannel Sleep Pant

A cozy tan cotton blend sleep pant with a drawstring waist and side pockets for comfort.
Women's Bean's Seacoast Seersucker Short Set

An ultralight seersucker short set in a breathable cotton blend with a relaxed fit and handy pockets.
Men's Bean's Cotton Knit Pajamas, Henley PJ Set
Price was from: $89 now: $74.99

A deep green henley pajama set made from 80% cotton and 20% recycled cotton for year-round comfort.
Women's Scotch Plaid Flannel Pajamas

A pair of ultrasoft Portuguese cotton flannel pajamas in Macrae Hunting Modern plaid for superior comfort and warmth.

Pros: Attractive design and color Superior comfort True to size fit Softness and coziness Warmth and durability
Men's Scotch Plaid Flannel Pajamas

A pair of ultrasoft 100% cotton flannel pajamas in black watch tartan, featuring a relaxed fit and elastic waistband.

Pros: High quality Attractive design Perfect fit Soft and comfortable Warmth
Women's Cozy PJ Set

A 100% cotton flannel pajama set in faded rose plaid with a henley neckline and contrast trim.

Pros: Fit Quality Comfort Cute print Warmth
Women's Cozy PJ Set, Print
Price was from: $69.95 now: $59.99

A cozy flannel pajama set in red snowflake forest print, featuring a henley top and drawstring pants.

Pros: Cozy fabric Cute print Beautiful colors Well made Comfortable fit
Women's Supima Nightgown, Short-Sleeve Floral
Price was from: $44.95 now: $34.99

A silky-soft blue nightgown made from 100% Supima cotton with a feminine scoop neckline.

Pros: Silky soft fabric Quick delivery Pretty design Great durability Comfortable fit
Women's Supima Cotton Nightgown, V-Neck Three-Quarter-Sleeve

A relaxed blue nightgown crafted from ultrasoft Supima cotton with three-quarter sleeves and a feminine V-neckline.

Pros: Lightweight and breathable Durable and retains shape Flattering fit and cut Soft and comfortable fabric Sleeve length is ideal
Women's Supima Nightgown, V-Neck Three-Quarter-Sleeve, Print
Price was from: $54.95 now: $44.99

A floral blue nightgown made from soft Supima cotton with a relaxed fit and feminine shirring.

Pros: Beautiful design Exceptional softness High quality Durable material Comfortable fit
Men's Comfort Stretch Woven Sleep Pants
Price was from: $59.95 now: $44.99

A pair of ultrasoft, stretch poplin sleep pants in bright mariner fish, perfect for year-round comfort.

Pros: Exceptional coziness High quality Perfect fit Great flexibility Comfortable length
Women's Restorative Sleepwear Sleep Pants
Price was from: $64.95 now: $54.99

A pair of lavender ice wide-leg sleep pants made from a soft 50% pima cotton and 50% modal blend.

Pros: Lightweight Comfortable waistband Durable Good fit Soft fabric

Cotton Blend Pajamas

When it comes to winding down after a busy day or enjoying a slow weekend morning, nothing feels quite as comforting as slipping into a well-made pair of cotton blend pajamas. The unique blend of cotton with other fibers brings together the best of both worlds: the familiar softness and breathability of cotton, paired with added durability and easy-care qualities that help pajamas hold their shape and color through countless washes. Whether you’re curling up with a good book, sharing popcorn during a family movie night, or savoring that first cup of coffee on the porch as the sun rises, cotton blend pajamas are designed to make those moments even cozier. Their lightweight feel makes them an ideal choice as the weather warms up in May, helping you stay cool and comfortable through the night, while still providing just enough warmth for those lingering spring breezes.

Cotton blend pajamas are a thoughtful and practical gift for anyone who values comfort and relaxation—whether you’re shopping for a high school graduate heading off to college, a friend celebrating a birthday, or a family member who deserves a little extra pampering. Their timeless styles and inclusive sizing options mean there’s something for everyone, from kids eager to pick out their favorite patterns to adults looking for classic designs that never go out of style. These pajamas are just as at home during a festive sleepover as they are during a quiet evening spent catching up with loved ones over video calls. For those who appreciate the simple joys of everyday life—like the fresh scent of laundry, the feel of crisp sheets, or the gentle rustle of leaves outside an open window—cotton blend pajamas become a cherished part of the nightly routine. If you’re searching for comfortable and versatile sleepwear, explore our collection of Women's Cotton PJs to find your new favorites.

Choosing the right pair of pajamas often comes down to personal comfort and practical needs. Cotton blend fabrics are beloved for their easy care and lasting value, resisting wrinkles and shrinkage while maintaining a soft touch wash after wash. They’re designed to move with you, stretching gently as you reach for the remote or tuck in the kids, and they’re crafted to stay comfortable on both cool spring nights and balmy summer mornings. Many families find themselves reaching for cotton blend pajamas not just at bedtime, but throughout the day—whether for a lazy Sunday breakfast, a quick dash to the mailbox, or even a relaxing afternoon nap. With a variety of styles, colors, and patterns to choose from, it’s easy to find pajamas that reflect your personality and fit seamlessly into your daily routine. Ultimately, cotton blend pajamas are more than just sleepwear—they’re an invitation to slow down, unwind, and enjoy the little things that make home feel special.

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Cotton Blend Pajamas